NOLTREX™ NOLTREX™ VET DAM™+
+7-495-223-70-95 RU EN

Osteoarthritis in an animal is not the end

NOLTREX™ - EFFECTIVE VISCOPROTHESIS FOR TREATMENT JOINT DISEASES IN ANIMALS

Synthetic hydrogel for lasting joint health

But the situation is not hopeless, and even in the late stages of osteoarthritis or other diseases accompanied by degenerative or traumatic damage to the articular cartilage, the animal has the opportunity to live a healthy and active life.

Effective for lameness and prolonged pain in the affected joint

NOLTREX™ effect lasts longer than of other treatments This is due to a special formula, thanks to which NOLTREX™ provides long-term viscosupplementation (maintains the viscous properties of the joint fluid)

Thanks to its unique formula and action, NOLTREX™ can help when other treatments have failed NOLTREX™ allows achieving the high results of therapy even in severe stages of the disease

Supportive treatment for cartilage pathology and osteochondral defects

Accumulates in areas of cartilage damage and physically protects tissues The experiment proved the presence of NOLTREX™ on the surface of the articular cartilage

Improves gliding and helps stabilize the synovial environment to maintain joint function The proven mechanisms of action of NOLTREX™ provide an effective therapy for continuous joint health

NOLTREX™ therapy is compatible with other joint treatments

NOLTREX™ intra-articular injections are compatible with systemic treatment NOLTREX™ is a synthetic inert hydrogel, therefore its use does not affect the effectiveness of systemic therapy for diseases of the musculoskeletal system

Other treatments do not affect the NOLTREX™ effects NOLTREX™ is eventually eliminated from the body through the tissue mechanisms of the joint, therefore systemic therapy does not change the effectiveness of NOLTREX™ after administration

The hydrogel is inert and highly compatible with tissues
NOLTREX™ has no local and systemic pharmacological, immunological and metabolic effects NOLTREX™ is an inert medical device, therefore it does not affect the surrounding organs and tissues

The presence of NOLTREX™ does not affect the properties and circulation of its own synovial fluid in the joint NOLTREX™ is mechanically mixed with synovial fluid without binding it, due to which the metabolism in the joint remains the same
Endoprosthesis protection
The polyacrylamide macromolecule is stabilized by 3-dymensional bonds, providing protection against biodegradation by hyaluronidases NOLTREX™ is a 100% high molecular weight synthetic material. The body lacks the enzymes that can quickly destroy it

The presence of trace amounts of silver ions in NOLTREX™ helps to protect the material from bacterial colonization * Silver ions maintain the sterility of the viscoprosthesis when inserted into a non-inflamed joint

* NOLTREX™ has no direct antibacterial effect and should be used when there is no risk of infection
Proven safe elimination from the body
The endoprosthesis undergoes complete biodegradation through hydrolysis and phagocytosis by synoviocytes NOLTREX™ gradually breaks down into small fragments, is captured by the cells of the joint and excreted from the body

Polyacrylamide is safely removed from the synovial environment and the body over time Scientifically proven completely safe excretion of NOLTREX™ from the body through the kidneys and liver

NOLTREX ™ is actively used in veterinary practice in Russia, EU, North America and other countries of the world. Currently, EQUISIT (Belgium) and Nucleus Regenerative Therapies, LLC (USA) are engaged in distribution and promotion activities of the product, the dealer networks of which cover the territories of the countries of the European Union, North America, Latin America, which undoubtedly indicates its high level of success.

Reviews on the use of NOLTREX™ in veterinary practice
Dmitry V. Zuev
Candidate of Veterinary Science. Chief veterinarian of the clinic VETMIR
"The dense endoprosthesis NOLTREX™ effectively reduced pain and improved movement in various joints in 18 crossover dogs or different breeds (ranging in size from Chihuahua to African Boerboel) between the ages of 1 and 12."

Russia, Moscow, Kurgan. Clinics Vetmir and Endovet.

Zuev D.V.
Trials of Noltrex for the treatment of dogs with osteoarthritis. Veterinary Medicine 2017. www.vetmir.ru
Читать дальше
Dina V. Andreeva
The member of the Veterinary Commission of the EFR (Equestrian Federation of Russia). Head of the Veterinary Service of equestrian center Bitsa. FEI Certified Treating Veterinarian
“The best cases for NOLTREX™ application are when the pathology is accompanied by a narrowing of the joint space with the existing cartilage damage and bone changes. Due to its physical properties, NOLTREX™ allows you to achieve maximum effect."

Russia, Moscow, Veterinary service of the equestrian center Bitsa.

Andreeva D.V.
Experience in the use of viscoprosthesis NOLTREX™ 2019. www.kskbitsa.ru
Читать дальше
Irina I. Viktorovna
Chief veterinarian of National Equestrian Park Rus LLC
"One of the key requirements for the products used by veterinary specialists in our clinic is high quality and reliability." Russia, Moscow region, Orlovo. National Equestrian Park Rus.

Ivanova I.V.
Experience in the use of viscoprosthesis NOLTREX™ 2019. www.horse-park.com
Читать дальше
PRE-CLINICAL, CLINICAL STUDIES AND PRACTICAL EXPERIENCE
Slesarenko NA, Shirokova EO
Reparative osteo- and chondrogenez in the conditions of induced osteoarthrosis in laboratory animals. Article, 2012.
PDF Мб)
Download
Shekhter AB, Zar VV
Tissue and cell reaction of the synovial media to intraarticular injection of polymer viscoprosthesis Noltrex in experimental conditions. Article, 2013.
PDF Мб)
Download
Khvisyuk AN, Pastukh VV, Dedukh NV
Prevention of post-traumatic adhesions around the Achilles tendons of rabbits. Article, 2014.
PDF Мб)
Download
McClure SR, Wang C
A preliminary field trial evaluating the efficacy of 4% polyacrylamide hydrogel in horses with osteoarthritis. Article, 2017
PDF Мб)
Download
McClure SR, Yaeger M, Wang C
Clinical and histologic evaluation of polyacrylamide gel in normal equine metacarpal /metatarsal-phalangeal joints. Article, 2017.
PDF Мб)
Download
Rojas DC, Arias MP, Duque D
Evaluation of an intra-articular polyacrylamide gel for the treatment of osteoarthritis of the distal joints of tarsus in horses. Trial, 2018.
PDF Мб)
Download
Zuev DV
Trial Noltrex for treatment dogs with osteoarthrosis. Article, 2016.
PDF Мб)
Download
Chernov AV, Emanov AA
Intracapsular arthroscopically assisted cranial cruciate ligament prosthetics of the dogs in situ. Article, 2018.
PDF Мб)
Download
Pastor N, Espadas L, Fragoso J
Efficacy of intra-articular polyacrylamide hydrogel in canine joints with osteoarthritis. Trial, 2019.
PDF Мб)
Download
Alvarez AV, Boone LH, Braim AP, Taintor JS
A survey of clinical usage of non-steroidal intra-articular therapeutics by equine practitioners. Article, 2020.
PDF Мб)
Download
IF YOU A VETERINARY DOCTOR, ANIMAL OWNER AND CARE FOR THE HEALTH OF YOUR PET

Join our Vkontakte or Facebook communities, or contact us via the feedback form below. Our specialists will try answering all your questions