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Osteoarthritis in an animal is not the end

NOLTREX™ - EFFECTIVE VISCOPROTHESIS FOR TREATMENT JOINT DISEASES IN ANIMALS

Synthetic hydrogel for lasting joint health

OSTEOARTHRITIS IN AN ANIMAL IS NOT THE END

Joint diseases are a very common pathology in horses, dogs, not only in large, but also in small breeds, as well as in other domestic animals. Every year from 10 to 40% of horses, dogs and cats suffer from musculoskeletal disorders. With osteoarthritis, patients suffer from lameness, local pain and edema, decreased activity, and depression.
Joint diseases therapy problems
  • the risks associated with anesthesia in elderly animals or animals with concomitant diseases
  • arthroscopy or arthroplasty of joints require complex equipment of the veterinary clinic
  • surgical treatment must be accompanied by animal rehabilitation
  • animal athletes are limited in terms of permitted treatment methods

But the situation is not hopeless, and even in the late stages of osteoarthritis or other diseases accompanied by degenerative or traumatic damage to the articular cartilage, the animal has the opportunity to live a healthy and active life.

NOLTREX™ HAS BEEN USED FOR OVER 8 YEARS IN ANIMALS. PROVEN EFFICIENCY HAS BEEN DEMONSTRATED IN VETERINARY PRACTICE AS WELL AS HIGH SAFETY OF ITS USE IN OVER 20,000 CASES

ABOUT NOLTREX™

NOLTREX™ IS USED AS A JOINT LUBRICANT
  • with physical properties identical to synovial fluid,
  • improving joint mobility,
  • increasing the volume of synovial fluid
WHAT IS NOLTREX™?
NOLTREX™ is a synthetic hydrogel consisting predominantly of high molecular weight 3-dimensional polyacrylamide (10 million Daltons). The polyacrylamide in NOLTREX™ has a molecular weight 3-5 times that of high molecular weight hyaluronic acid (the main component of normal joint fluid). When injected into a joint, a substance with a higher molecular weight degrades for a longer time, therefore, the effect of treatment remains longer than that of a product with a smaller molecule size. Thus, NOLTREX™ has a huge advantage over other treatments that improve the viscoelastic properties of the joint fluid.
HOW DOES NOLTREX™ WORK?
NOLTREX™ substitutes the joint fluid of the damaged joint with weakened lubricating properties. Due to its properties, NOLTREX™ reduces friction and provides physical protection for the sensitive articular cartilage. Cartilage protection is critical to keeping the joints healthy and free from pain.

NOLTREX™ PROVIDES EFFECTIVE TREATMENT FOR HORSES AND SMALL COMPANION ANIMALS FOR VARIOUS STAGES OF JOINT DISEASES

Proven efficacy of NOLTREX™

Effective for lameness and prolonged pain in the affected joint

NOLTREX™ effect lasts longer than of other treatments This is due to a special formula, thanks to which NOLTREX™ provides long-term viscosupplementation (maintains the viscous properties of the joint fluid)

Thanks to its unique formula and action, NOLTREX™ can help when other treatments have failed NOLTREX™ allows achieving the high results of therapy even in severe stages of the disease

Supportive treatment for cartilage pathology and osteochondral defects

Accumulates in areas of cartilage damage and physically protects tissues The experiment proved the presence of NOLTREX™ on the surface of the articular cartilage

Improves gliding and helps stabilize the synovial environment to maintain joint function The proven mechanisms of action of NOLTREX™ provide an effective therapy for continuous joint health

NOLTREX™ therapy is compatible with other joint treatments

NOLTREX™ intra-articular injections are compatible with systemic treatment NOLTREX™ is a synthetic inert hydrogel, therefore its use does not affect the effectiveness of systemic therapy for diseases of the musculoskeletal system

Other treatments do not affect the NOLTREX™ effects NOLTREX™ is eventually eliminated from the body through the tissue mechanisms of the joint, therefore systemic therapy does not change the effectiveness of NOLTREX™ after administration

Mechanism of action of NOLTREX™ is a long-term viscosupplementation

NOLTREX™ HAS A PROTECTIVE EFFECT ON JOINT TISSUES
Restores joint function
Provides effective viscosupplementation to reduce friction and maintain the natural viscoelastic properties of the joint environment Due to its viscoelastic properties and an increase in the total volume of fluid in the joint after administration, NOLTREX™ separates joint surfaces and creates a shock-absorbing effect

NOLTREX™ helps to physically restore the functionality of the joint, which leads to a decrease in pain and inflammation Provides protection for the articular cartilage, eliminates a constant irritant in the joint, which caused pain and inflammation
Immediate cartilage protection
NOLTREX™ acts as a separating lubricant, reducing friction and protecting cartilage Due to the normalization of viscoelastic properties and separation of the articular surfaces, NOLTREX™ ensures their protection

Forms a surface layer on the articular cartilage even in lesion NOLTREX™ effectively covers the cartilage, prevents its mechanical damage
Prolonged cartilage protection
Reduction of physical micro trauma and surface friction minimizes further cartilage destruction NOLTREX™ preserves the integrity of the cartilage, stopping its further destruction for a long time

Repeated injections of long-lasting hydrogel NOLTREX™ are safe and an effective treatment option for animals NOLTREX™ can be used repeatedly as maintenance treatment at intervals of several months or more

NOLTREX™ DOES NOT AFFECT THE NATURAL METABOLISM IN THE SYNOVIAL ENVIRONMENT AND IS SAFELY EXCRETED FROM THE BODY

High safety of NOLTREX™ use

The hydrogel is inert and highly compatible with tissues
NOLTREX™ has no local and systemic pharmacological, immunological and metabolic effects NOLTREX™ is an inert medical device, therefore it does not affect the surrounding organs and tissues

The presence of NOLTREX™ does not affect the properties and circulation of its own synovial fluid in the joint NOLTREX™ is mechanically mixed with synovial fluid without binding it, due to which the metabolism in the joint remains the same
Endoprosthesis protection
The polyacrylamide macromolecule is stabilized by 3-dymensional bonds, providing protection against biodegradation by hyaluronidases NOLTREX™ is a 100% high molecular weight synthetic material. The body lacks the enzymes that can quickly destroy it

The presence of trace amounts of silver ions in NOLTREX™ helps to protect the material from bacterial colonization * Silver ions maintain the sterility of the viscoprosthesis when inserted into a non-inflamed joint

* NOLTREX™ has no direct antibacterial effect and should be used when there is no risk of infection
Proven safe elimination from the body
The endoprosthesis undergoes complete biodegradation through hydrolysis and phagocytosis by synoviocytes NOLTREX™ gradually breaks down into small fragments, is captured by the cells of the joint and excreted from the body

Polyacrylamide is safely removed from the synovial environment and the body over time Scientifically proven completely safe excretion of NOLTREX™ from the body through the kidneys and liver

Application of NOLTREX™ for joint diseases

How effective is NOLTREX™ compared to other joint treatments?
There are many different types of joint therapies available to veterinary practitioners today. However, in a recent survey of leaders in veterinary medicine, NOLTREX™ was found to be highly effective. NOLTREX™ intra-articular injections have been used when standard treatment gave poor results.
Which joints can NOLTREX™ be injected into?
NOLTREX™ can be injected into any synovial joint. NOLTREX™ was originally recommended for the supportive treatment of joints with high motion. However, other joints with low motion, providing limited but important movement, also showed significant improvement with NOLTREX™ therapy.
How long does it take for the NOLTREX™ effect to appear?
The response to NOLTREX™ treatment may vary depending on the individual characteristics of the animal. For example, in some patients, improvement is observed within a few days after injection, in others, the effect is formed for up to 30 days. Typically, gradual improvement is seen over 1–3 weeks. If indicated, the veterinarian may prescribe repeat injections after a while.

Product instructions

Recommendations for use in horses
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Dosage regimen of NOLTREX™ in horses
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Recommendations for use in dogs
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Dosage regimen of NOLTREX™ in dogs
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*The instruction, intended for users in Russia and the CIS countries, is available only in Russian

Worldwide recognition of NOLTREX™

NOLTREX™ IS ACTIVELY USED IN VETERINARY PRACTICE IN RUSSIA, THE EU, THE USA AND OTHER COUNTRIES OF THE WORLD. CURRENTLY, THE DISTRIBUTION AND PROMOTION OF THE PRODUCT IS CARRIED OUT BY EQUISIT© (BELGIUM) AND NUCLEUS PROVETS, LLC (USA), WHOSE DEALER NETWORKS COVER THE TERRITORIES OF THE EUROPEAN UNION, NORTH AND LATIN AMERICA, AND UNDOUBTEDLY INDICATES A HIGH LEVEL OF PRODUCT SUCCESS.

Reviews on the use of NOLTREX™ in veterinary practice

"The safety and efficacy of single and multiple injections of NOLTREX™ into the elbow joint after arthroscopy has been demonstrated in 207 cases in 88 dogs of various breeds."

Poland, Warsaw. Wydziału Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego
Kowalczyk P. Clinical pilot study. Safety of single and repeated intra-articular injection of a 4% polyacrylamide hydrogel after elbow arthroscopy. ESVOT Congress 2021.
Dmitry V. Zuev
Candidate of Veterinary Science. Chief veterinarian of the clinic VETMIR
"The dense endoprosthesis NOLTREX™ effectively reduced pain and improved movement in various joints in 18 crossover dogs or different breeds (ranging in size from Chihuahua to African Boerboel) between the ages of 1 and 12."

Russia, Moscow, Kurgan. Clinics Vetmir and Endovet.

Zuev D.V.
Trials of Noltrex for the treatment of dogs with osteoarthritis. Veterinary Medicine 2017. www.vetmir.ru
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Dina V. Andreeva
The member of the Veterinary Commission of the EFR (Equestrian Federation of Russia). Head of the Veterinary Service of equestrian center Bitsa. FEI Certified Treating Veterinarian
“The best cases for NOLTREX™ application are when the pathology is accompanied by a narrowing of the joint space with the existing cartilage damage and bone changes. Due to its physical properties, NOLTREX™ allows you to achieve maximum effect."

Russia, Moscow, Veterinary service of the equestrian center Bitsa.

Andreeva D.V.
Experience in the use of viscoprosthesis NOLTREX™ 2019. www.kskbitsa.ru
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Irina I. Viktorovna
Chief veterinarian of National Equestrian Park Rus LLC
"One of the key requirements for the products used by veterinary specialists in our clinic is high quality and reliability." Russia, Moscow region, Orlovo. National Equestrian Park Rus.

Ivanova I.V.
Experience in the use of viscoprosthesis NOLTREX™ 2019. www.horse-park.com
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58.7% OF VETERINARY DOCTORS IN THE USA USING INTRA-ARTICLE INJECTIONS OF POLYACRYLAMIDES FOR HORSE TREATMENT PRESCRIBE NOLTREX™, WHICH IMPROVES THE VISCOELASTIC PROPERTIES OF SYNOVIA.

Slesarenko NA, Shirokova EO
Reparative osteo- and chondrogenez in the conditions of induced osteoarthrosis in laboratory animals. Article, 2012.
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Shekhter AB, Zar VV
Tissue and cell reaction of the synovial media to intraarticular injection of polymer viscoprosthesis Noltrex in experimental conditions. Article, 2013.
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Khvisyuk AN, Pastukh VV, Dedukh NV
Prevention of post-traumatic adhesions around the Achilles tendons of rabbits. Article, 2014.
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McClure SR, Wang C
A preliminary field trial evaluating the efficacy of 4% polyacrylamide hydrogel in horses with osteoarthritis. Article, 2017
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McClure SR, Yaeger M, Wang C
Clinical and histologic evaluation of polyacrylamide gel in normal equine metacarpal /metatarsal-phalangeal joints. Article, 2017.
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Rojas DC, Arias MP, Duque D
Evaluation of an intra-articular polyacrylamide gel for the treatment of osteoarthritis of the distal joints of tarsus in horses. Trial, 2018.
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Zuev DV
Trial Noltrex for treatment dogs with osteoarthrosis. Article, 2016.
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Chernov AV, Emanov AA
Intracapsular arthroscopically assisted cranial cruciate ligament prosthetics of the dogs in situ. Article, 2018.
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Pastor N, Espadas L, Fragoso J
Efficacy of intra-articular polyacrylamide hydrogel in canine joints with osteoarthritis. Trial, 2019.
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Alvarez AV, Boone LH, Braim AP, Taintor JS
A survey of clinical usage of non-steroidal intra-articular therapeutics by equine practitioners. Article, 2020.
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IF YOU A VETERINARY DOCTOR, ANIMAL OWNER AND CARE FOR THE HEALTH OF YOUR PET

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