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Arthritis in an animal is not the end.

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NOLTREX Vet is an effective product for the treatment of joint diseases in animals.
It is a 100% synthetic, non-soluble hydrogel that acts as a lubricant. Noltrex is injected directly into the joint and does not need to be metabolized to have an effect. Essentially, it is a substitute for compromised synovial fluid and helps improve joint function.
Joint pain and lameness are common in horses, large breeds of dogs and other domestic animals. But the situation is not hopeless. Even in severe late-stage cases, the animal still has the opportunity to live a healthy and active life.
NOLTREX is used to provide lubrication in conditions such as
  • Osteoarthritis (Arthrosis)
  • Chondromalacia
  • Osteochondrosis and cystic lesions
  • Post operatively as a joint lavage
Mechanism of action NOLTREX Vet
Noltrex reduces friction
The products coats the joint services with a thin lubricating film and thus reduces friction. By limiting friction, one of the primary irritants that lead to pain and inflammation in the joint is mitigated.
Protection of Cartilage
When injected into the joint, NOLTREX covers the joint surfaces. It creates a cushioning effect, preserves the integrity of the cartilage, and inhibits further destruction. NOLTREX is designed to mimic the physical properties of synovial fluid and provides an additional layer of joint protection where it acts as a boundary lubricant.
Re-establishing healthy joint lubrication
NOLTREX has characteristics similar to normal joint fluid. Once injected, it helps normalize the physical properties of the intra-articular environment.
NOLTREX has been used for more than 10 years around the world in the treatment of osteoarthrosis in humans and for more than 5 years in animals. It has an excellent safety record and has proven therapeutically beneficial in thousands of cases.
Protection of cartilage
NOLTREX is designed to mimic the physical properties of synovial fluid and provides an additional layer of joint protection where it acts as a boundary lubricant.
High viscosity and stability of the hydrogel
The viscosity of NOLTREX ™ is similar to the viscosity of synovial fluid in an animal. In contrast to hyaluronic acid-based products, Noltrex remains effective in the joint much longer due to its very large size and synthetic composition. Its molecular weight is 10million Dalton – 5x more than even high molecular hyaluronic acid.
Pain relief
By reducing the permanent irritation caused by friction and physically protecting the joint, a root cause of pain and inflammation is reduced, often after just one injection.
High degree of biocompatibility
NOLTREX ™ does not affect the surrounding organs and tissues, does not migrate in the body, does not cause allergic or rejection reactions
100% synthetic high molecular weight hydrogel
Due to the high molecular weight and synthetic character, the lack of enzymes in the body that can destroy the gel, the product remains in the joint for many weeks and is eventually ground down physically and gradually removed from the body.
Sterility of the implant
Noltrex contains traces of silver ions which helps maintain the long term sterility of the product inside the joint.
NOLTREX ™ is recognized internationally
NOLTREX ™ is actively used in veterinary practice in Russia, EU, North America and other countries of the world. Currently, EQUISIT (Belgium) and Nucleus Regenerative Therapies, LLC (USA) are engaged in distribution and promotion activities of the product, the dealer networks of which cover the territories of the countries of the European Union, North America, Latin America, which undoubtedly indicates its high level of success.
Client Testimonials
Zuev Dmitry Vyacheslavovich.
Candidate of veterinary sciences. Chief veterinarian of the clinic "Vetmir"
The product NOLTREX is a new joint lubricant of European quality that allows to significantly improve the life of patients with osteoarthritis. It allows correcting the viscosity of the synovial fluid that was lost as a result of the disease, and thus it helps to reduce articular cartilage degeneration. The hydrogel is relatively convenient to use, but it should be noted that it has a sufficiently high density and its administration under the supervision of a veterinarian is carried out for 15-20 seconds, which in some cases requires sedation of the patient. It is possible to periodically introduce this viscous prosthesis in dogs with chronic osteoarthrosis (1-2 times in 6-12 months). With the help of Noltreх, the pain syndrome is suppressed and the motor function of the joint is restored, which greatly improves the quality of life of patients. The use of Noltrex is justified from an economic point of view against the backdrop of costly surgical intervention.
Andreeva Dina Vladimirovna
Member of the veterinary committee of the Equestrian Federation of Russia, head of the veterinary service of the equestrian complex "Bitsa"
With the viscous prosthesis "Noltrex" my colleagues and I have been working for more than 5 years. We repeatedly applied it in different situations, when the lameness of the horse is a consequence of the articular pathology. This allowed us to accumulate some experience and determine the patterns, when from its application one should expect the greatest efficiency. It is necessary to say at once that in the treatment of lameness in horses accompanied by degenerative pathologies of the joints, we apply a comprehensive approach. Use of Noltrex is usually the final stage of treatment, preceded by anti-inflammatory therapy and the use of intra-articular chondroprotectors. The scheme of treatment of horses with acute lameness is as follows: first we introduce a chondroprotective drug with hyaluronic acid and an anti-inflammatory component (deposited GCS), which aims to extinguish the inflammatory process. After 10-20 days, we inject Noltrex, pre-injecting into the joint cavity a little anesthetic and SCS of short action, which should prevent possible pain syndrome, which the manufacturer warns about. By the way, in none of the cases with Noltrex application according to this scheme we observed pain syndrome or other anxiety of the animal, or a nonspecific reaction from the joint. With planned preventive actions on a horse that has chronic degenerative joint changes, but is not limping at the moment, the treatment scheme is similar, but without the use of deposited GCS. For one of my old patients, horses with pronounced degenerative carpal osteoarthritis, I apply Noltrex twice a year, giving it 10-14 days of light work after injection, and the horse is able to carry athletic loads without long interruptions for treatment and without lameness. In our experience, the best cases for use of Noltrex are when articular pathology is accompanied by a narrowing of the joint gap, including with the already existing cartilage damage and arthrosis bone changes, with arthrolytes present. In this case Noltrex, due to its physical properties, allows to achieve the maximum effect of "spreading" the articular surfaces, which are inflammed and irritated, also mechanically protecting the joint in this way. This eliminates the constant irritant, breaking the vicious circle of "trauma - inflammation - trauma", which is very favorable for the result of treatment. We injected Noltrex into different joints: ungulate, coronary, hock, carpal, knee. Large joints had to use a larger amount of the drug. In some cases, the introduction had to be repeated. The maximum number of injections introduced is 4 times, for a horse with large ungulate arthritis, whose owners did not have the possibility of surgical treatment. The positive effect was achieved, the horse runs and returned to the sporting load.
Ivanova Irina Viktorovna
The Chief Veterinary Doctor of LLC "NKP" Rus "
One of the key requirements for the medical preparations used by veterinarians of our clinic, and the owners of animals to be recommended is the high quality and reliability of them. Medical device "Noltrex" for many years of application in the treatment of osteoarthritis in horses has proved its high efficacy and safety, and therefore this joint lubricant was included in the main list of standard preparations used in our clinic for the treatment of arthritis in horses.
Instruction for use for NOLTREX in veterinary practice
PDF (1.4 Мб)
Application of NOLTREX in arthritis treatment in equines
official recommendations for horse breeders from RC BIOFORM, LLC
PDF (1.4 Мб)
Morphological and functional preconditions for knee joint injuries in members of the canine family.
Dissertation by Shirokova E. O.
PDF (1.4 Мб)
Reparative osteo- and chondrogenesis in conditions of induced osteoarthritis in laboratory animals.
Article by Slesarenko N.A., Shirokova E.O.
PDF (1.4 Мб)
Application of NOLTREX in arthritis treatment in dogs.
Article by Zuev D.V.
PDF (23.3 Мб)
Optimization of reparative chondrogenesis in induced gonarthrosis in animals.
Article by Slesarenko N.A., Shirokova E.O.
PDF (11.2 Мб)
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